At the beginning of the 18th century, Japan was under the rule of the Tokugawa Shogunate. At that time, a malignant disease called "red blister" was prevalent on the island, and all patients were male. This disease was stubborn and difficult to treat, leading to a continuous increase in the number of deaths and a serious gender imbalance in Japan. The Kishimoto samurai Mizuno family residing in Edo
At the beginning of the 18th century, Japan was under the rule of the Tokugawa Shogunate. At that time, a malignant disease called "red blister" was prevalent on the island, and all patients were male. This disease was stubborn and difficult to treat, leading to a continuous increase in the number of deaths and a serious gender imbalance in Japan. The Kishimoto samurai Mizuno family residing in Edo